李沉简
李沉简，男，1969年10月出生，毕业于美国普渡大学，前任北京大学元培学院常务副院长、生命科学学院教授。
人物经历
教育经历
工作经历
1997年至2003年在美国纽约Rockefeller大学从事博士后研究工作。
2003年至2009年在美国康奈尔大学医学院任助理教授。
2009年至2010年在美国康奈尔大学医学院任副教授。
2016年任北京大学元培学院常务副院长。
北京大学生命科学学院教授。
主要成就
科研成就
论文
1. Zheng, S.,Geghman, K., Shenoy, S., Li, C , Retake the Center Stage - New Development of Rat Genetics. , Journal of Genetics and Genomics. , 2012 , 39(6):261-8.
2. Yong Huang and Chenjian Li , Proteasome dysfunction in 动物界 models for PINK1 Parkinson’s disease , J Neurogenetics , 2012 , 26(2):158-67
3. Qing Xu, Sushila Shenoy and Chenjian Li , Mouse Models for LRRk2 Parkinson’s Disease , Parkinsonism and Related Disorders , 2012 , 18, 186-189.
4. Dagda R, Gusdon A, Pien I, Strack S, C Li, Cherra J, and Chu C. , Mitochondrially localized PKA reverses mitochondrialpathology and dysfunction in a cellular model of Parkinson's disease. , Cell 死亡 and Differentiation. , 2011 , 18, 1914-1923.
5. Kindiya Geghman and Chenjian Li , ractical consideration of genetic rodent models for neurodegenerative disease. , Methods in 摩尔 Biol. , 2011 , 793:185-193.
6. Wencheng Liu, Rebeca Acin-Perez, Kindiya Geghman, Giovanni Manfredi, Bing Wei Lu and Chenjian Li , Pink1 regulates the assembly of oxidative phosphorylation machinery via mitochondrial fission , Proc Natl Acad Sci.USA. , 2011 , 108, 12920-12924.
7. Cristofol Vives-Bauza, Chun Zhou, Yong Huang, VAlina Dawson, Darren More, Grailhe, Ted Dawson, Chenjian Li, Serge Przedborski. , PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. , Proc Natl Acad Sci. USA. , 2010 , 107, 378-383.
8. Wencheng Liu, Cristofol Vives-Bauza, Rebeca Acin-Perez, Ai Yamamoto, Yingcai Tan, Yanping Li, Jordi Magrane, , Mihaela Stavarache, Michael Kaplitt, Xin-Yun Huang, M. Flint Beal, Giovanni Manfredi and Chenjian Li , Mutant PINK1 causes mitochondrial dysfunction, proteasomal deficit and α-synuclein aggregation in Parkinson’s disease models. , PLoS ONE. , 2009 , 4(2): e4597.
9. Yanping Li, Wencheng Liu, Tinmarlar F. Oo, Lei Wang, Yi Tang, Vernice Jackson-Lewis, Chun Zhou, Kindiya Geghman, Serge Przedborski, M.Flint Beal Robert Burke and Chenjian Li , BAC transgenic mouse model for LRRK2 recapitulates robust Parkinson’s disease phenotypes. , Nature 神经科学 , 2009 , 12, 826-828.
10. Younghwa Kim, Ping Zhou, Liping Qian, Jesica Lee, Chenjian Li, Constantino Iadecola, Carl Nathan and Aihao Ding. , MyD88-5 links mitochondra, microtubules and JNK3 in Neurons and regulates Neuronal survival. , J. Exp Medicine (Cover). , 2007 , 204(9):2063-74.
11. Chenjian Li and M Flint Beal. , Leucine-rich repeat kinase 2: a New player with a familiar theme for Parkinson’s disease pathogenesis. , Proc Natl Acad Sci. USA. , 2005 , 102, 16535-16537.
12. Tsu-kang Sang, Chenjian Li, Lawrence Zipursky, George Jackson. , Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. , Hum 摩尔 獛属 , 2005 , 14(3):357-72
13. Xiaofeng Gu, Chenjian Li, Weicheng Wei, Victor Lo, Shiaoching Gong, Shihua Li, TAkuji Iwasato, Shigeyoshi Itohara, XiaoJiang Li, Istvan Mody, Nathaniel Heintz, William Yang, , Pathological cell-cell interactions elicited by a neuropathogenic form of mutant huntingtin contribute to cortical pathogenesis in HD mice. , Neuron. , 2005 , 46, 433-444.
14. Chenjian Li, Wayne Brake, Russell Romeo, Marisa Gordon, Rodica Buzescu, Patrick Allen, Paul Greengard, Bruce McEwen , Hippocampal neuron dendritic spine maturation, synaptic proteins immunoreactivity and 表演 in spatial learning tasks in mice. , Proc Natl Acad Sci.USA. , 2004 , 101, 2185-90.
15. Shaoching Gong, William Yang, Chenjian Li, Nathaniel Heintz , Highly Efficient Modification of Bacterial Artificial Chromosomes (BACs) Using Novel Shuttle Vectors Containing the R6Kr Origin of Replication. , Genome Research. , 2002 , 12:1992-1998.
16. Bruce McEwen, Keith Akama, Steve Alves, Wayne Brake, Chenjian Li, Yuen G , Tracking the estrogen receptor in neurons: implications for estrogen-induced synapse formation. , Proc Natl Acad Sci USA. , 2001 , 98:7093-7100.
17. Milner, T. A., McEwen, B. S., Hayashi, S., Chenjian Li, Reagan, L. P., Alves, S. E. , Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites. , J Comp Neurol. , 2001 , 429(3)355-371.
18. Chenjian Li, Chaoxian Geng, Hung-Tat Leung, Young Seok Hong, Lydia R. Strong, William L. Pak. , InaF, a Protein Required For Transient Receptor Potential ca(clo)2+ Channel 函数 , Proc Natl Acad Sci.USA. , 1999 , 96(23):13474-13479.