李红岩
李红岩,女,副教授,目前主要从事教学、科研,为本科生开设《细胞工程》课程。
人物经历
2002-至今 任中国海洋大学副教授;
2004-2007期间为宇宙ité Pierre et Marie Curie, France 博士后。
研究方向
发育生物学:
1)早期发育中基因的功能研究;
2)鱼类的免疫与进化。
主要贡献
科研项目
RNA结合蛋白Seb4的表达调控以及在斑马鱼肌肉发生中的功能 国家自然科学基金 主持 2009-2011;
核糖核酸结合蛋白在斑马鱼早期发育中的功能研究 教育部留学回国人员基金 主持 2009-2010;
鱼类抗感染免疫的分子与细胞基础及其调控 973 参加;
IgM的母体传递及其免疫保护作用的机理研究 海洋所开放课题 主持。
发表论文
1. Bourdelas#, HY Li#, C. Carron and D.L. Shi 2009 Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development. Int. J. Dev. Biol. 53: 1075-1079;
2. Li HY, Bourdelas A., Carron C., Boucaut J., Gomez C.. Shi DL. 2006, FGF8, Wnt8 and Myf5 are target genes of Tbx6 during anteroposterior specification in Xenopus embryo. Dev. Biol. 290: 470-481.;
3. Shao M, Liu ZZ, Wang CD, Li HY, Carron C, Zhang HW, Shi DL. 2009 Down Syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in 脊椎动物 embryos. Development 136(12):2121-31.;
4. Grandy D, Shan J, Zhang X, Rao S, Akunuru S, Li HY, Zhang Y, Alpatov I, Zhang XA, Lang RA, Shi DL, Zheng JJ. 2009 Discovery and characterization of a small 摩尔cule inhibitor of the PDZ domain of dishevelled. J Biol. Chem. 284(24):16256-63;
5. Liu ZH, Li L, Li HY, Zhang SC, Ji GD, Sun YL. 2009 EST analysis of the immune-relevant genes in Chinese amphioxus challenged with lipopolysaccharide. Fish Shellfish Immun3-甲基-3-戊醇 26(6):843-9.;
6. Bourdelas A., Li HY., Boucaut J., Shi D. Identification of distinct genes with restricted expession in the somitic mesoderm in xenopus embryo. Gene Expression Patterns 2004, 4: 695-699.
7. Liu M., Zhang S., Liu Z., Li H., Xu A. Characterization, organization and expression of AmphiLysC, an acidic c-type lysozyme gene in amphioxus Branchiostoma belcheri tsingtauense. Gene 2006, 367: 110-117.;
8. Li H., Zhang vitro cytotoxicity of the organophorous pesticide 甲基parathion to FG-9307 cells. Cell 生物学 and 毒理学 2002, 8: 235-241.;
9. Li H., Zhang S. In vitro cytotoxicity of the organophorus pesticide parathion to FG-9307 cells. Toxicology in Vitro 2001, 15: 643-647.
10. Carron C., Bourdelas A., Li HY, Boucaut J., Shi DL. Antagonistic interaction between IGF and Wnt/JNK signaling in convergent extension in Xenopus embryo. Mechanisms of Development 2005, 122: 1234-1247.;
11. HY Li, S.C. Zhang, M. Wang and M. Jiang, 2001 In vitro study on cytotoxic effects of the organophosphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus) Chinese Journal of Oceanology and Limnology 19(1): 57-62;
12. Wang Y, Zhang S, Liu Z, Li H, Wang L. Identification and expression of amphioxus [beta]-microseminoprotein (MSP)-like gene encoding an ancient and rapidly evolving protein in chordates. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular 生物学 2005; 142:251-57.
13. Wang Y, Zhang S, Liu Z, Li H, Wang L. Characterization and expression of AmphiCL encoding cathepsin l proteinase from amphioxus Branchiostoma belcheri tsing金牛座ense. Marine biotechnology 2005; 7:279-86.
14. Luan J, Liu Z, Zhang S, Li H, Fan C, Li L. Characterization, evolution and expression of the calmodulin1 genes from the amphioxus Branchiostoma belcheri tsingtauense. Acta Biochim Biophys Sin (Shanghai). 2007; 39:255-64.
15. Wang Y, Zhang S, Liu Z, Li H, Wang L. Amphioxus allantoicase: molecular cloning, expression and enzymatic activity. Comparative biochemistry and physiology. 2005; 141:237-43.
16. Wang L, Zhang SC, Liang SD, Liu ZH, Li HY, Wang YJ. Characterization and expression of AmphiARF gene encoding a new member of ARF family from amphioxus Branchiostoma belcheri tsing金牛座ense. 脱氧核糖核酸 Sequence - The Journal of Sequencing and Mapping. 2005; 16:418-25.
17. Liu Z, Zhang S, Li H, et al. Characterization and expression profile of AmphiCD63 encoding a novel member of TM4SF proteins from amphioxus Branchiostoma belcheri tsingtauense. DNA Seq. 2005; 16:195-201.
18. Li X, Zhang S, Liu Z, Li H. Ribosomal Protein Genes S23 and L35 from Amphioxus Branchiostoma belcheri tsingtauense: Identification and Copy Number. Acta Biochimica et Biophysica Sinica. 2005; 37: 573-79.
19. Wang L, Zhang S, Liu Z, Li H, Wang Y, Jiang S. 2007 Characterization and expression of amphioxus ApoD gene encoding an archetype of 脊椎动物 ApoD proteins. Cell Biol Int. 31:74-81.
20. G. S.C. Zhang and HY Li, 2001 Ultrastructural localization and antibacterial activity of phenoloxidase in amphioxus Branchiostoma belcheri tsingtauense. Journal of the Marine Biological Association of the United Kingdom 81: 705-706
21. S.C. Zhang, L. Li, and H.Y. Li, 2002 Histochemical localization of constitutive nitric oxide synthases in amphioxus Branchiostoma belcheri tsingtauense. Journal of the Marine Biological Association of the United Kingdom 82: 1041-1042
22. H.R. Guo, sven co-op Zhang, and HY Li, 2003 Spontaneous neoplastic transformation of the cell line FG-9307 of the flounder (Paralichthys olivaceus) North American Journal of AQUAculture 65: 44-48
23. H.R. Guo, S.C. Zhang and H.Y. Li, 2002 Characterization of lactate dehydrogenase isozyme pattern and morphology of three marine fish cell lines of FG, SPH and RSBF. Chinese Journal of Oceanology and Limnology 20(3): 246-251
24. L. Li, S.C. Zhang, J.D.Yuan and HY Li, 2003 Development of inter-family nulear transplant embryos by transplanting the the nuclei from the loach blastulae into the non-enucleated zebrafish eggs. Chinese Journal of Oceanology and Limnology 21(1): 64-71
获奖记录
1. 国家海洋局科技进步一等奖,第三位,2003年;
2. 教育部自然科学二等奖,第四位,2006年。