樊武舫
樊武舫，男，河东人。耶鲁大学虫媒病毒学硕士，耶鲁大学分子遗传学博士，加利福尼亚州圣迭戈柯尔曼大学分子生物学与生物信息学教授，哈佛大学博士后，现任河北大学生命科学学院教授。
人物生平
樊武舫博士上世纪70年代参军；1982年2月毕业于中国人民解放军第三军医大学基础医学部并获微生物学与免疫学硕士学位。留校后任微生物学讲师，后任教研室党支部书记（正团职单位）。1985年被学员以最高票数评为全校模范教师，荣获全军优秀教师称号，立军队三等功一次。同年考取世界卫生组织分子病毒学奖学金，于1986年12月份进入美国哈佛大学医学院微生物学及分子遗传学系，历任该系访问学者和讲师；在诺贝尔奖得主John F. Enders（1954年诺贝尔奖得主，脊髓灰质炎疫苗的奠基人）病毒实验室从事核糖核酸病毒及缺损病毒的研究，并从此开始在国际著名学术杂志发表研究论文。1988年接受世界著名虫媒病毒学家Robert Shope教授的邀请，就读于《耶鲁大学文理科学研究生院》，从事刚果出血热病毒和乙脑病毒糖蛋白基因的研究，于1990年获病毒学硕士学位。同年转入耶鲁大学遗传系成为人类分子遗传学博士研究生，师从于著名分子遗传学家Sherman M. Weissman教授(美国科学院资深院士，美国国立卫生研究院NIH遴选的20位研究基金终身获得者之一)，同时受教于细胞生物学教授George E. Palade博士(1974年生理学和医学诺贝尔奖获得者)。1993年底完成博士研究论文，被授予PhD博士学位。博士论文题目为《在人类主要组织相容性抗原位点（MHC）第一区段发现，定位和鉴定39个非免疫相关的新基因》。樊武舫博士在MHC第一区段首次发现的嗅觉受体基因，FAT10基因（一种泛素蛋白修饰基因），和具有锌带蛋白质结构的转录因子NZRD1基因，在人类生殖行为，神经科学，MHC功能学及肿瘤学研究方面，引起很大反响。世界多家著名实验室对其所发现的新基因进行积极深入的研究。仅在国内，科学院上海某研究所和第三，空军军医大学已将上述后两个基因列为肿瘤研究的重点课题。
樊武舫博士于1994年受聘于美国劳伦斯国家实验室人类基因组国家研究中心，任资深研究员并参与指导加利福尼亚大学学生（和诺贝尔奖化学奖得主Glenn T Seaborg共同指导在美国劳伦斯国家实验室的实习生）。1997年受聘于美国Gene Logic公司任高级研究员及疾病基因研究部主任，取得一系列成果并开始在美国专利局申请肿瘤和疾病相关基因的技术专利。2001年受聘于美国OriGene公司任基因分析部主任。由于其在人类基因组研究方面的精湛造诣，他在一年多的时间里就获得二十多项基因专利。从2002年7月开始，受聘于加州Immusol药物研发公司，出任生物信息学部主任，其研究成果亦获得数个技术专利。从2006年下半年起，任圣地亚哥柯尔曼大学分子生物学及生物信息学教授。
教育背景
耶鲁大学分子病毒学硕士，耶鲁大学人类分子遗传学博士，霍普金斯大学生物信息学职业文凭，加利福尼亚州圣迭戈柯尔曼大学分子生物学与生物信息学教授，哈佛大学博士后。
学者经历
美国上市GeneLogic生物制药公司疾病基因研究部主任，美国加州圣地亚哥市柯尔曼学院分子生物学及生物信息学教授，纽约科学院院士，现任河北大学生命科学学院二级教授，学术委员会主任。
研究方向
1.肿瘤基因的发现分离与鉴定。靶肿瘤为国内和省内高发肿瘤如肺癌，肝癌，胃癌，食管癌等。方法采用DNA芯片筛选法等。
2.肿瘤的特异标记蛋白（biomarker）及其在临床的诊断应用。
3.肿瘤的免疫研究。主要研究特异的DCs（树突状细胞）及相关的抗原提呈细胞（APC），NK细胞，单核细胞和粒性白细胞及其分泌的细胞因子在肿瘤免疫和致病机理中的作用。
4.肿瘤的治疗，探讨使用溶瘤病毒和慢病毒属携带的si核糖核酸s对肿瘤进行治疗的可能性并评价其疗效。
5.分离与动植物特殊性状相关的基因及其在生产实践中的应用。
6.分子分类学技术
7.生物信息学与NCBI镜像资料库在中国的建立。
主要作品
部分论文
1.Ning Ke,Wufang Fanet al (2007) Orphan G-protein coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway. Molecular Cancer Therapeutics.6(6):1840-50
2.Jiangping Yang,Wufang Fan, Cheryl Rogers, Jon E. Chatterton, Cui-Ying Wang, Joshua Bliesath, Guohong Liu, Ning Ke, Kristina Rhoades, Flossie Wong-Staal, Qi-Xiang Li(2006)A novel RNAi library based on partially randomized consensus sequences of nuclear receptors: Identifying the receptors involved in amyloid beta degradation. Genomics 88(3):282-92.
3. Dehua Yu; Wufang Fan; Guohong Liu; Vivian Nguy; Jon E Chatterton; Shilong Long; Ning Ke; Bernd Meyhack; Adrian Bruengger; Arndt Brachat; Flossie Wong-Staal. (2006). PHTS, a novel putative tumor suppressor gene, is involved in the transformation reversionOf HeLaHF cells independently of the p53 pathway. Experimental Cell Research. 312(6):865-76, 2006.
4.Ke, N; Claassen, G; Yu, D-H; Albers, A; Fan W;Tan, P; Grifman, M; Hu, X; DeFife, K; Nguy, V; Meyhack, B; Brachat, A; Wong-Staal, F; and Li, Q-X.(2004).Nuclear Hormone Receptor NR4A2 is involved in 细胞 transformation and Apoptosis.Cancer Research64: 8208-8212.
5.Fan, W.Wang, Z.H., Kyzysztof, F.,Prange, C., and Lennon, G. (2000).A new zinc ribbon gene (NZRD1) is cloned from the human MHC class I region.Genomics63:139-141.(One of the figures in the paper was chosen as the cover of this issue of Genomics).
6.Liu, Y.C., pan, J., Zhang C.,Fan, W., Collinge, M., Bender, JR., and Weissman,SM. (1999).A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2.Proc Natl Acad Sci U S A. 96(8): 4313-4318.
7.Dosanjh, M.K., Collins, D.W.,Fan, W.,Lennon, G.G.,Albala, J.S.,Shen, Z., Schild,D.(1998).Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.Nucleic Acids Res.26:1179-84
9. Liu, N., Lamerdin, J.E.,Tebbs, R.S.,Schild, D.,Tucker, J.D.,Shen,M.R.,Brookman,K.W.,Siciliano,M.J.,Walter,C.A.,Fan, W.,Narayana, L.S.,Zhou, Z.Q.,Adamson, A.W.,Sorensen, K.J.,Chen, D.J.,Jones, N.J., and Thompson, L.H.(1998).XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against 脱氧核糖核酸 cross-links and other damages.摩尔 细胞 1998 1: 783-93.
10. Prange, C.K., Pennacchio,L.A., Lieuallen, K.,Fan, W., and Lennon, G. (1998). Characterization of the human neurocan Gene, CSPG3.Gene 221:199-205.
11. Albala, J.S., Thelen, M.P., Prange, C.,Fan, W., Christensen, M., Thompson, L.H., and Lennon, G.G. (1997)Identification of a novel human RAD51 homolog, RAD51B, Genomics 46: 476-479:
12.Fan, W., Christensen, M., Eithler, E., Zhang, X., and Lennon, G. (1997).Cloning, sequencing, gene organization and localization of the human ribosomal protein rp L23agene.Genomics.46:234-239.
13.Gruen, J.R.,Nalabolu, S.R.,Chu, T.W.,Bowlus, C.,Fan, W.,Goei, V.L.,Wei H., Sivakamasundari R.,Liu Y.C.,Xu, H.X., Parimoo, S.,Nallur,G.,Ajioka, R., Shukla, H., Bray-Ward, P., pan, J., and Weissman S.M. (1996).A transcription map of the major histocompatibility complex (MHC) class I region.Genomics, 36:70-85
14.Fan, W., Cai, W.,Parimoo, S., Lennon, G., and Weissman, M.S. (1996).Identification of seven new human MHC class I region genes around the HLA-F locus.Immunogenetics. 44: 97-103
15.Fan, W.,Liu, Y.C.,Parimoo, S., and Weissman, S.M. (1995). Olfactory 捕手like genes are located in the human major histocompatibility complex.Genomics. 27: 119-123.
16.Fan, W., Wei H., Xu, H., Parimoo,S.,Shukla, H., Chaplin D..D., and Weissman, M.S. (1993).Genes in one megabase of the HLA class I region.Proc. Natl. Acad. Sci. USA. 90: 11870-11874.(The first two authors contributes to this paper equally)
17.Fan, W., Wei, X., Shukla, H., Parimoo, S., Xu , H.X., Sankhavaram, P., Li, Z., and Weissman, M.S. (1993).Application of cDNA Selection Techniques to Regions of the Human MHC.Genomics.17:575-581
18.Fan, W., and Mason, paul wurth (1990).Membrane Association and Secretion of the Japanese 脑炎 病毒 NS1 Protein from Cells Expressing NS1 c脱氧核糖核酸Virology 177:470-476.
19.Fan, W., Chen, S.T., and Huang, A.S., (1989).Multiple Thermolabile and 温度Sensitive Lesions in Mutant tl17 of Vesicular Stomatitis 病毒Intervirology 30:148-155.
20.Fan, W., Yu, S.R., and Cosgriff, T.M.Revolution (1989).The re-emergence of Dengue inChina(1989). Rev Infect Dis.11:S847-853.
21.Fan, W.（1988）Basic and clinical medicine: their 组合 and mutual promotion.
Technology Review 6 (8802): 32-34.
22.Fan, W., Li, G.P., and Zhu, D.Z. (1987).Purification and Analysis of the Hemagglutinin of the Russian Spring-Summer 脑炎 病毒Chinese Journal of Zoonoses. 3:456-461.
23.Fan, W.,Ren, D.X., and Zhu, D.Z. (1986).Detection of Specific IgM Antibodies to Russian Spring-Summer Virus in Patient Acute-Phase Serum by ELISA and its Application in Diagnosis. Chinese Journal of Zoonoses. 2:327-332.
24.Fan, W., Liu, Q.F., and Zhu, D.Z. (1986).A Practical Approach for Concentration and Purification of the Russian Spring-Summer 脑炎 病毒 from Infected Mouse Brains.Acta of theTTMMUMedicalUniversity. 4:283-287.
25.Fan, W., Liu, Q.F., and Zhu, D.Z. (1984).An Indirect Peroxidase Antibody Test(IPA) for Detection of Specific Antibodies to Hemorrhagic Fever with Renal 综合征 病毒 in Patient Serum. Medical Journal of PLA. 9:333-337.
26.Fan, W., and Zhu, D.Z. (1984).Establishment of an Indirect ELISA for Detection of Specific IgG Antibodies to Russian Spring-Summer 脑炎 Virus in Patient serum and its Potential Application in Clinical Diagnosis.Chinese Journal of Medicine in Epidemiology.5:107-112.
27.Fan, W. (1984).The New Advance in Study of the Etiological Agents for Hemorrhagic Fever
with Renal Syndromes(HFRS).Reviews of Foreign Medicine. 5:10-14.
28.Fan, Wand Zhu, DZ:Virology of thehemorrhagic feverwith renal 综合征Foreign
Medicineof ClinicalBiochemistry andLaboratory Medicine：1984(Z1)
29Fan, W. Li, G.P., and Zhu, D.Z. (1983).A Modified Hemagglutination Inhibition Test for
Diagnosis of Russian Spring-Summer Encephalitis Patients. Chinese Journal of Medicine
in Epidemiology. 4:372-375.
30Fan, W.(1981).The Application of ELISA in Diagnostic Virology.Reviews of Medicine in
the World.3:1-9.
摘要及专利
樊武舫博士2006-2007年在美国国家专利局申请的部分专利内容及专利号(其它专利号从略)：
Wufang Fan- Patents \u0026 Inventors, bibliographic references
Recent bibliographic sampling of patent applications for Wufang Fanlisted/published in the public domain by the 美国专利及商标局 (USPTO Patent Application # Title):
Year: 2006 to 2007, Patent ID#
1. 20070184459 - Methods of inhibiting cancer growth by binding to nuclear receptors
2. 20070087984 - Method of identifying agents that inhibit the growth of cancer cells
3. 20060241015 - Cancer genes
1. Methods of inhibiting cancer growth by binding to nuclear receptors
Abstract: The present invention provides methods for identifying agents useful for inhibiting cancer cells by binding to various nuclear receptor proteins, or to the genes or RNA encoding such proteins. (end of abstract)
2. Method of identifying agents that inhibit the growth of cancer cells
Abstract: The present invention is directed to methods of identifying agents useful for inhibiting cancer cells. The agents bind to one of the proteins described herein, or to a gene or mRNA encoding such protein. The invention is also directed to methods for inhibiting cancer cells by administering an agent that binds to one of the proteins described herein, or to a gene or mRNA encoding such protein. (end of abstract)
3. Cancer genes
Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially expressed in prostate and breast cancers and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., cancers. (end of abstract)
出版著作
樊武舫博士曾主编或与他人合编出版了多种书籍，其中包括合编出版的《医学微生物学》是军医大学五年制学生的重要教材（1985第三军医大学出版），主编出版的《美国主要大学及研究生院介绍》是中国的畅销书之一（1985，重庆人民出版社），全国各大学及各图书馆均将其作为馆藏书目。合编出版的中文版和英文版《分子生物学实用技术》在中美同时发行（Practical Protocols in Molecular Biology，Science Beijing/New York, 1996）；以及新近与他人合编出版的《新药药物靶标开发技术》已在中国发行（2006，高教社）。
ABSTRACTS AND PRESENTATIONS
1.Fan, W.D:CD40 expression in gastric adenocarcinoma. Abstract forASHG/ICHG 2011
Meeting inMontreal,Canada, October 11-15.
2.Fan, W., Lennon, G.A simple differential and quantitative PCR method to replace Northern
analysis.The 10th International Congress on Genes, Gene Families, and Isozymes.
Beijing,China, October 4-10, 1999.
3.Fan, W.., Wang, Z.H., Kyzysztof, F., Prange, C., and Lennon, G.Cloning of a new zinc ribbon gene from the human MHC class I region.48Th Annual Meeting of The American Society of Human Genetics.October 27-31, 1998.Denver,Colorado.
4.Fan, W.,and Lennon, G.Gene organization, chromosome locationand full-length cDNA sequencing of the human rp L23agene.47th Annual Meeting of The American Society of Human Genetics.October 28-November 1, 1997.Baltimore,Maryland.
5.Fan, W.., Lennon, G.G., Mohrenweiser, HoneyWorks, and Eithler, E.E.Identification of the triplet repeat containing genes: Potential candidate for neurological disorders.46th Annual Meeting of The American Society of Human Genetics.October 29 to November 2, 1996.San Francisco.
6.Fan, W.., Liu, Q.C., Parimoo, S., and Weissman, M.S: Olfactory receptor-like gene identified from human MHC class I region and its possible biological significance.The 9th International Immunology Conference.San Francisco, July 23-28, 1995.
7.Fan, W.,Parimoo, S., Weissman,M.S.: Large scale identification of expressed sequences by hybridization cDNA selection.The 4th international workshop on identification of transcribed sequences from genomic DNA.October 15-17,蒙特利尔,Canada, 1994.
8.Fan, W.., Parimoo, S., Weissman,M.S and et al: Newnon-classical class I genes in the human MHC class I region.Organ Conference.Vermont,USA.July, 1994.
9.Fan, W.., Parimoo, S., and Weissman,M.S.: 39 new genes found in the MHC class I region by novel approach: the c脱氧核糖核酸 selection.The 12th Eurapean Immunology Conference.Barcelona,Spain.June 14-17, 1994.
10.Fan, W.., Wei, H., Xu, H., Sheila, H., Parimoo, S., Bowlus, C., Chaplin, D., Gruen, J., and Weissman, M.S.:Cloning expressed sequences from the HLA class I region.The 9th International H-2/HLA Cloning Workshop.PoliclinicodiBorgoRoma.Italy. May, 1994
11.Wei, H.,Fan, W.., Shukla,H., Parimoo, S., Xu, H.X, Chaplin, D., Freije, D and Weissman,M.S.: cDNA selection of the MHC class I region.Second annual chromosome 6 workshop,Berlin,Germany.September 18-19, 1993
12.Fan, W.,Parimoo, S., Shukla, H.,Patanjali,S.,Li, Z and Weissman, MS.,: Discovering, mapping and characterization of 35 new genes in human MHC class I region covering one megabase chromosomal DNA by cDNA selection.The first symposium on life sciences and biotechnology for Chinese scientists overseas and at home.Beijing, P.R.China. August 17-21, 1993
13.Shukla, H., Hongxia, X., Bonds, W., Parimoo, S., Sivakamasundari, R.,Fan, W.,Gardiner, H.K. and Weissman, S.M.: Large scale mapping of short fragment c脱氧核糖核酸 on chromosome 21 long arm. Fourth International Workshop on Chromosome 21,Paris,France, April 23-24, 1993.
14.Weissman, S.M., Shukla, H., Parimoo, S.,Fan, W.,Patanjali, S.R., Gruen, JR., Chaplin, D.D., Expressed sequences in the human MHC.First International Workshop on Chromosome 6,UniversityofMichigan,Ann Arbor, June 7-9, 1992.
15.Parimoo, S., Shukla, H.,Fan, W.,Patanjali, S.R., Chaplin, D.D and Weissman, S.M: Hybridization selection is an efficient method for identifying cDNAs encoded in large DNA fragments.ColdSpringHarborLaboratory Meeting on "Genome Mapping and Sequencing," May 6-10, 1992.
16.Shukla, H.,Fan, W.., Parimoo, S., Chaplin, D.D., Mathur, R., Chorney, M.J. and Weissman
, S.M:, Approaches for rapid identification of cDNA encoded in MHC.Chapel Hill, nc, April
1-5, 1992.
主要成就
先后发表三十余篇原始科学发现论文，总影响因子达1167，平均每篇文章的影响因子接近四十。独立或与他人合作共申请了30多项基因和生物药靶专利，主编或与他人合编在美国和中国出版集团有限公司论著四部。其论文之一曾作为世界著名基因组学杂志《Genomics》的封面刊出（2000年第一期），以此纪念该杂志进入21世纪。
业余爱好
本人业余爱好为中国古典文学，中国古文字学和中国上古历史。对山西省西南部河东地区上古历史及其演变具有强烈的兴趣。其中包括：女娲，燧人氏和黄帝的关系；河汾交汇处黄帝部落及其祖先的起源与存在；（黄）河汾（河）交汇处与中国上古文化与社稷祭祀的关系；汾河盆地的古生态与尧舜禹兴起；河东地区尧舜禹的历史遗迹及口头传说。河东方言中的文言文及上古语言的遗存；渭河平原文化与河东文化的关系及归属。河东望族薛姓在汉晋隋唐宋各个历史时期的政治作用和文学地位；唐代著名书画家薛稷对现代中文书写方式的确立以及在仿宋体创立中的作用；明清以来黄河小北干流河道的演变及其对山西省地区人文历史/政治经济学/人口迁徙的影响；全新世中期气候变化与河东人文历史演变的关系等。
学者荣誉
2000年被世界著名人物杂志《Who is Who》评选收录为引导美国生物学进入21世纪的500名生物科学家之一。由于他在生物学领域的杰出贡献，于2005年6月14日被美国总统布什邀请到白宫参加总统晚餐。